Should I Take My Antidepressant at Night or in the Morning

Should I Take My Antidepressant at Night or in the Morning Depression Treatment Medication Print Should I Take My Antidepressant at Night or in the Morning? Time It Right to Avoid Adverse Effects By Nancy Schimelpfening Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. Learn about our editorial policy Nancy Schimelpfening Medically reviewed by Medically reviewed by Steven Gans, MD on August 05, 2016 Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Learn about our Medical Review Board Steven Gans, MD Updated on February 04, 2020 Depression Overview Types Symptoms Causes & Risk Factors Diagnosis Treatment Coping ADA & Your Rights Depression in Kids Paul Bradbury / Getty Images Determining if you should take your antidepressant at night or in the morning depends on the specific medication youre taking, its side effects, and how it influences your quality of life. Your prescribing doctor may suggest a specific time of day for you to take your antidepressant to minimize any common adverse  effectsâ€"commonly insomnia or drowsinessâ€"that may be associated with your particular prescription, but there are other factors to take into consideration as well. Insomnia Some antidepressantsâ€"such as Celexa (citalopram), Zoloft (sertraline), and Effexor (venlafaxine)â€"have sustained-release formulations, and do not appear to be any more or less effective when taken at varying times of the day. However, some selective serotonin reuptake inhibitors (SSRIs), the class to which these medications belong, can disrupt sleep for some people and would be best taken in the morning.?? For example, the manufacturer of Prozac (fluoxetine)  recommends it be taken in the morning because it can make some people feel more energized, especially at the beginning of treatment. When Prozac is given in combination with Zyprexa (olanzapine)â€"a combination called Symbyaxâ€"as a therapy for treatment-resistant depression, its recommended to be taken in the evening as it can cause sleepiness. Paxil (paroxetine) is generally taken in the morning in order to prevent sleeplessness at night. However, it may be given at bedtime if it is found to cause drowsiness in the person taking it. Wellbutrin  (bupropion) is another antidepressant that is recommended to be taken in the morning in order to prevent insomnia at night.?? Drowsiness Unlike some SSRIs, certain other antidepressants tend to make you feel drowsy, so theyre better tolerated if you take them at bedtime.  Among these medications are Luvox (fluvoxamine), Remeron (mirtazapine), and the tricyclic antidepressants,?? including: Elavil (amitriptyline)Norpramin (desipramine)Tofranil (imipramine)Pamelor (nortriptyline) Sexual Issues If you experience sexual side effects (such as low libido, erectile dysfunction, or inability to ejaculate) from your antidepressant, the timing of when you take your antidepressant can make a difference. Taking medications like  Zoloft  (sertraline) or  tricyclic antidepressants  after you have sex may ensure the levels of the drug in your body are lowest at the time of sexual activity. If youre someone who experiences sexual side effects from your antidepressant, consider your pattern of sexual activity when you’re deciding when to take your medication. For example, if you are most likely to get frisky in the evening, taking your pill in the morning may work best for you. Nausea Some classes of antidepressants (mostly SSRIs) can trigger nausea as well as vomiting, diarrhea, and loss of appetite. While this often resolves itself as your body adjusts to the medication, sticking to a nighttime medication schedule can also help by hopefully allowing you to sleep through any digestive woes. Urinary Problems When prescribed in  children  or  adolescents, Zoloft can cause frequent urination as well as urinary incontinence. In this case, taking the pill in the morning can prevent any nighttime bedwetting. Side Effect When to Take Medication Insomnia Morning Drowsiness Bedtime Sexual Issues Morning Nausea Bedtime Urinary Problems Morning Other Optimal Medication Strategies In addition to discussing with your doctor the time of day that is best to take your antidepressant, its critical to remember that there are other strategies that affect how well your medication will work, including: Having patience. Antidepressants take time to work; potentially anywhere from 6 to 12 weeks for the full effect,?? although many people notice improvement within a week or two. When you start your antidepressant, keep in close contact with your doctor and stay positiveâ€"you can find a way to treat your condition, but it may take a little bit of trial and error.Staying consistent. Take your antidepressant as directed at the same time every day and do not stop it without first talking to your doctor.Addressing side effects. If your antidepressant is causing side effects, remember that many, if not all of them, will go away with time. If the side effects are intolerable, get in touch with your doctor right away, as there is a solution, such as a dose change, switching to a different antidepressant, or adding a second medication to manage the offensive side effect. A Word From Verywell Taking an antidepressant needs to be part of a well-thought-out plan with your doctor to maximize its benefits and minimize any potential side effects. Dont make any changes to your treatment plan without consulting with your doctor first; the recommendations noted above are general and may or may not be applicable to your own unique situation.   Your doctor will be able to provide you with specific recommendations about whether your antidepressant should be taken at a particular time of day for the best results for you.